diff --git a/cmd/issues.go b/cmd/issues.go
index 05ce2f0..41bd4c7 100644
--- a/cmd/issues.go
+++ b/cmd/issues.go
@@ -63,6 +63,7 @@ var CmdIssues = cli.Command{
 		&issues.CmdIssuesEdit,
 		&issues.CmdIssuesReopen,
 		&issues.CmdIssuesClose,
+		&issues.CmdIssuesDependencies,
 	},
 	Flags: append([]cli.Flag{
 		&cli.BoolFlag{
diff --git a/cmd/issues/dependencies.go b/cmd/issues/dependencies.go
new file mode 100644
index 0000000..0038170
--- /dev/null
+++ b/cmd/issues/dependencies.go
@@ -0,0 +1,227 @@
+// Copyright 2025 The Gitea Authors. All rights reserved.
+// SPDX-License-Identifier: MIT
+
+package issues
+
+import (
+	"bytes"
+	stdctx "context"
+	"encoding/json"
+	"fmt"
+	"strconv"
+	"strings"
+
+	"code.gitea.io/sdk/gitea"
+	"code.gitea.io/tea/cmd/flags"
+	"code.gitea.io/tea/modules/api"
+	"code.gitea.io/tea/modules/context"
+	"code.gitea.io/tea/modules/print"
+	"code.gitea.io/tea/modules/utils"
+
+	"github.com/urfave/cli/v3"
+)
+
+// CmdIssuesDependencies represents the subcommand for issue dependencies
+var CmdIssuesDependencies = cli.Command{
+	Name:        "dependencies",
+	Aliases:     []string{"deps", "dep"},
+	Usage:       "Manage issue dependencies",
+	Description: "List, add, or remove dependencies for an issue",
+	ArgsUsage:   "<issue index>",
+	Action:      runDependenciesList,
+	Commands: []*cli.Command{
+		&cmdDependenciesList,
+		&cmdDependenciesAdd,
+		&cmdDependenciesRemove,
+	},
+	Flags: flags.AllDefaultFlags,
+}
+
+var cmdDependenciesList = cli.Command{
+	Name:        "list",
+	Aliases:     []string{"ls"},
+	Usage:       "List dependencies for an issue",
+	Description: "List issues that the specified issue depends on (blockers)",
+	ArgsUsage:   "<issue index>",
+	Action:      runDependenciesList,
+	Flags:       flags.AllDefaultFlags,
+}
+
+var cmdDependenciesAdd = cli.Command{
+	Name:        "add",
+	Usage:       "Add a dependency to an issue",
+	Description: "Make an issue depend on another issue (blocker)",
+	ArgsUsage:   "<issue index> <dependency index or owner/repo#index>",
+	Action:      runDependenciesAdd,
+	Flags:       flags.AllDefaultFlags,
+}
+
+var cmdDependenciesRemove = cli.Command{
+	Name:        "remove",
+	Aliases:     []string{"rm"},
+	Usage:       "Remove a dependency from an issue",
+	Description: "Remove a dependency from an issue",
+	ArgsUsage:   "<issue index> <dependency index or owner/repo#index>",
+	Action:      runDependenciesRemove,
+	Flags:       flags.AllDefaultFlags,
+}
+
+// runDependenciesList lists dependencies for an issue
+func runDependenciesList(ctx stdctx.Context, cmd *cli.Command) error {
+	c := context.InitCommand(cmd)
+	c.Ensure(context.CtxRequirement{RemoteRepo: true})
+
+	if cmd.Args().Len() < 1 {
+		return fmt.Errorf("issue index required")
+	}
+
+	index, err := utils.ArgToIndex(cmd.Args().First())
+	if err != nil {
+		return err
+	}
+
+	client := api.NewClient(c.Login)
+	path := fmt.Sprintf("/repos/%s/%s/issues/%d/dependencies", c.Owner, c.Repo, index)
+
+	var deps []*gitea.Issue
+	if _, err := client.Get(ctx, path, &deps); err != nil {
+		return err
+	}
+
+	if len(deps) == 0 {
+		fmt.Printf("Issue #%d has no dependencies\n", index)
+		return nil
+	}
+
+	print.IssuesPullsList(deps, c.Output, []string{"index", "state", "title", "owner", "repo"})
+	return nil
+}
+
+// runDependenciesAdd adds a dependency to an issue
+func runDependenciesAdd(ctx stdctx.Context, cmd *cli.Command) error {
+	c := context.InitCommand(cmd)
+	c.Ensure(context.CtxRequirement{RemoteRepo: true})
+
+	if cmd.Args().Len() < 2 {
+		return fmt.Errorf("usage: tea issues dependencies add <issue index> <dependency index or owner/repo#index>")
+	}
+
+	index, err := utils.ArgToIndex(cmd.Args().First())
+	if err != nil {
+		return fmt.Errorf("invalid issue index: %w", err)
+	}
+
+	depOwner, depRepo, depIndex, err := parseDependencyArg(cmd.Args().Get(1), c.Owner, c.Repo)
+	if err != nil {
+		return err
+	}
+
+	client := api.NewClient(c.Login)
+	path := fmt.Sprintf("/repos/%s/%s/issues/%d/dependencies", c.Owner, c.Repo, index)
+
+	reqBody := api.IssueDependencyRequest{
+		Owner: depOwner,
+		Repo:  depRepo,
+		Index: depIndex,
+	}
+
+	body, err := json.Marshal(reqBody)
+	if err != nil {
+		return fmt.Errorf("failed to marshal request: %w", err)
+	}
+
+	if _, err := client.Post(ctx, path, bytes.NewReader(body), nil); err != nil {
+		return err
+	}
+
+	if depOwner == c.Owner && depRepo == c.Repo {
+		fmt.Printf("Added dependency: issue #%d now depends on #%d\n", index, depIndex)
+	} else {
+		fmt.Printf("Added dependency: issue #%d now depends on %s/%s#%d\n", index, depOwner, depRepo, depIndex)
+	}
+	return nil
+}
+
+// runDependenciesRemove removes a dependency from an issue
+func runDependenciesRemove(ctx stdctx.Context, cmd *cli.Command) error {
+	c := context.InitCommand(cmd)
+	c.Ensure(context.CtxRequirement{RemoteRepo: true})
+
+	if cmd.Args().Len() < 2 {
+		return fmt.Errorf("usage: tea issues dependencies remove <issue index> <dependency index or owner/repo#index>")
+	}
+
+	index, err := utils.ArgToIndex(cmd.Args().First())
+	if err != nil {
+		return fmt.Errorf("invalid issue index: %w", err)
+	}
+
+	depOwner, depRepo, depIndex, err := parseDependencyArg(cmd.Args().Get(1), c.Owner, c.Repo)
+	if err != nil {
+		return err
+	}
+
+	client := api.NewClient(c.Login)
+	path := fmt.Sprintf("/repos/%s/%s/issues/%d/dependencies", c.Owner, c.Repo, index)
+
+	reqBody := api.IssueDependencyRequest{
+		Owner: depOwner,
+		Repo:  depRepo,
+		Index: depIndex,
+	}
+
+	body, err := json.Marshal(reqBody)
+	if err != nil {
+		return fmt.Errorf("failed to marshal request: %w", err)
+	}
+
+	if _, err := client.Delete(ctx, path, bytes.NewReader(body)); err != nil {
+		return err
+	}
+
+	if depOwner == c.Owner && depRepo == c.Repo {
+		fmt.Printf("Removed dependency: issue #%d no longer depends on #%d\n", index, depIndex)
+	} else {
+		fmt.Printf("Removed dependency: issue #%d no longer depends on %s/%s#%d\n", index, depOwner, depRepo, depIndex)
+	}
+	return nil
+}
+
+// parseDependencyArg parses a dependency argument which can be:
+// - "123" or "#123" (same repo)
+// - "owner/repo#123" (cross-repo)
+func parseDependencyArg(arg, defaultOwner, defaultRepo string) (owner, repo string, index int64, err error) {
+	// Check for cross-repo format: owner/repo#123
+	if strings.Contains(arg, "/") && strings.Contains(arg, "#") {
+		parts := strings.SplitN(arg, "#", 2)
+		if len(parts) != 2 {
+			return "", "", 0, fmt.Errorf("invalid dependency format: %s (expected owner/repo#index)", arg)
+		}
+
+		repoPath := parts[0]
+		indexStr := parts[1]
+
+		repoParts := strings.SplitN(repoPath, "/", 2)
+		if len(repoParts) != 2 {
+			return "", "", 0, fmt.Errorf("invalid dependency format: %s (expected owner/repo#index)", arg)
+		}
+
+		owner = repoParts[0]
+		repo = repoParts[1]
+
+		index, err = strconv.ParseInt(indexStr, 10, 64)
+		if err != nil {
+			return "", "", 0, fmt.Errorf("invalid issue index: %s", indexStr)
+		}
+
+		return owner, repo, index, nil
+	}
+
+	// Same repo format: 123 or #123
+	index, err = utils.ArgToIndex(arg)
+	if err != nil {
+		return "", "", 0, fmt.Errorf("invalid issue index: %w", err)
+	}
+
+	return defaultOwner, defaultRepo, index, nil
+}
diff --git a/modules/api/client.go b/modules/api/client.go
index 31b2a4d..1f2649c 100644
--- a/modules/api/client.go
+++ b/modules/api/client.go
@@ -97,3 +97,48 @@ func (c *Client) GetRaw(ctx context.Context, path string) ([]byte, error) {
 
 	return body, nil
 }
+
+// Post makes an authenticated POST request to the API and decodes the JSON response
+func (c *Client) Post(ctx context.Context, path string, body io.Reader, result interface{}) (*http.Response, error) {
+	return c.doRequest(ctx, "POST", path, body, result)
+}
+
+// Delete makes an authenticated DELETE request to the API
+func (c *Client) Delete(ctx context.Context, path string, body io.Reader) (*http.Response, error) {
+	return c.doRequest(ctx, "DELETE", path, body, nil)
+}
+
+// doRequest performs an HTTP request with the given method
+func (c *Client) doRequest(ctx context.Context, method, path string, body io.Reader, result interface{}) (*http.Response, error) {
+	url := fmt.Sprintf("%s/api/v1%s", c.login.URL, path)
+
+	req, err := http.NewRequestWithContext(ctx, method, url, body)
+	if err != nil {
+		return nil, fmt.Errorf("failed to create request: %w", err)
+	}
+
+	req.Header.Set("Authorization", "token "+c.login.Token)
+	req.Header.Set("Accept", "application/json")
+	if body != nil {
+		req.Header.Set("Content-Type", "application/json")
+	}
+
+	resp, err := c.httpClient.Do(req)
+	if err != nil {
+		return nil, fmt.Errorf("failed to execute request: %w", err)
+	}
+	defer resp.Body.Close()
+
+	if resp.StatusCode >= 400 {
+		respBody, _ := io.ReadAll(resp.Body)
+		return resp, fmt.Errorf("API request failed with status %d: %s", resp.StatusCode, string(respBody))
+	}
+
+	if result != nil {
+		if err := json.NewDecoder(resp.Body).Decode(result); err != nil {
+			return resp, fmt.Errorf("failed to decode response: %w", err)
+		}
+	}
+
+	return resp, nil
+}
diff --git a/modules/api/types.go b/modules/api/types.go
index 7ecce2b..a2e03e4 100644
--- a/modules/api/types.go
+++ b/modules/api/types.go
@@ -57,3 +57,10 @@ type ActionJobList struct {
 	TotalCount int64        `json:"total_count"`
 	Jobs       []*ActionJob `json:"jobs"`
 }
+
+// IssueDependencyRequest is the request body for adding/removing issue dependencies
+type IssueDependencyRequest struct {
+	Owner string `json:"owner"`
+	Repo  string `json:"repo"`
+	Index int64  `json:"index"`
+}